Alabama Patent of the Month – March 2021

Age Related Macular Degeneration is the leading cause of legal blindness in developed countries. Damage to the retina causes a loss of vision in the macula which is the center of your vision. One form of AMD – atrophic – can lead to blindness over the course of many years. The more severe form – neovascular – can result in blindness within 1 year of onset. There is no treatment for atrophic AMD and treatment for neovascular AMD has only 50% efficacy. MacRegan, Inc has designed a topical treatment which can be used for any type and any stage of AMD.

MacRegan’s method involves the use of cell-penetrating peptides (CPP) to effectively deliver the treatment. The treatment is a combination of therapeutic agents like antioxidants and anti-inflammatories, as well as complement inhibitors and neuroprotectors which help to direct the pathway of the treatment. These components are combined with CPPs and administered topically either by eyedrops or a coated contact lens. The treatment works to protect the retina and other components of the eye and prevent damage and scarring which results in blindness. This comprehensive use means it can be used to help prevent AMD from starting, help prevent progression of AMD, and can help with other similar eye disorders as well.

About MacRegen, Inc.

MacRegen is a pre-clinical stage biotechnology company seeking to develop, register, and commercialize first-in-class breakthrough drugs, given alone or in combination with other drugs for the treatment of both dry and wet AMD. The Company has already completed a Preferred Series A round of financing. The Company believes that by targeting the primary etiology of AMD, its new drug Mitia™ may provide unprecedented treatments and prevention of all forms of AMD.

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