Arkansas Patent of the Month – April 2025
A novel approach to cancer immunotherapy has emerged with the development of Mi-2β inhibitors, designed to counteract tumor resistance to immune checkpoint blockade therapies. This innovation is detailed in U.S. Patent No. 12,268,674, titled “Mi-2β inhibitor as an immunotherapy agent,” assigned to BioVentures, LLC. (patents.justia.com)
Disrupting Tumor Defense Mechanisms
The patented method involves administering an effective amount of a Mi-2β inhibitor to a subject or directly contacting cancer cells or tumors with the inhibitor. By targeting Mi-2β, a component of the NuRD chromatin remodeling complex, the therapy aims to disrupt the tumor’s ability to evade immune detection. This disruption can potentially enhance the effectiveness of existing immunotherapies by making resistant tumors more susceptible to immune system attacks.
Potential Impact on Cancer Treatment
The introduction of Mi-2β inhibitors represents a significant advancement in the field of cancer treatment, particularly for patients whose tumors have developed resistance to current immunotherapy options. By focusing on the epigenetic mechanisms that tumors use to suppress immune responses, this approach offers a new avenue for enhancing the efficacy of cancer immunotherapies.
As research progresses, the application of Mi-2β inhibitors could become a pivotal component in the treatment of various cancers, providing hope for improved outcomes in cases where traditional immunotherapies have failed.(patents.justia.com)
Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.
Who We Are:
Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.
Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.
