Delaware Patent of the Month – January 2022
In some treatment methods, reducing cell viability has great potential. Reducing the viability, inducing cell apoptosis (cell death), and inhibiting cell spread could, for instance, treat cancer by preventing it from spreading and inducing its own self-death. Cyclooxygenase (COX) is an enzyme linked to cancer pathogenesis. As such, there have been attempts at creating anti-cancer treatments targeting COX-2. However, these attempts are limited by the appearance of toxic side effects. These effects range from nephrotoxicity to cardiotoxicity.
GLAX, LLC, a biomedical R&D company, has developed a method of reducing cell viability without introducing these common toxic side effects. The company has developed a controlled-release treatment which combines anticancer effects with anti-inflammatory effects. This treatment uses Prostaglandin Endoperoxide Synthetase-2 (PTGS-2) inhibitors. PTGS-2 is a gene which encodes for COX-2. By inhibiting the gene, COX-2 is inhibited and therefore cancer pathogenesis is limited. With the combination of anticancer and anti-inflammatory help to limit toxic side effects while delivering reduced cell viability.
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