Hawaii Patent of the Month – June 2025
U.S. Patent No. 12338209, titled Astaxanthin esters and methods of use thereof, introduces novel ester forms of astaxanthin with improved stability, absorption, and health impact.
Innovation in Astaxanthin Forms
The new patent outlines tertiary amino ester versions of astaxanthin. These compounds resist degradation under heat and moisture. They also absorb better than regular astaxanthin. This could make them more effective in real-world health products.
Health Advantages and Mechanism
CARDAX INC. highlights that these esters lower inflammation markers such as CRP, TNF‑α, IL‑6, and oxidized LDL. They also raise HDL cholesterol and activate protective genetic pathways like FOXO3. These effects suggest benefits for heart, metabolic, and inflammatory health.
Cost‑Effective Production
The ester compounds are made in a single chemical step from astaxanthin without complex purification. That could lower manufacturing costs and support mass production. It means more affordable, stable supplements or pharmaceuticals.
From Patent to Patient
This patent paves the way for clinical trials of an astaxanthin “pro‑drug.” The design directly tackles long-standing delivery and shelf‑stability challenges. If trials confirm benefits, these esters may become practical tools in managing cardiovascular and inflammatory health.
The patent represents a meaningful step toward real-world antioxidant therapies built on natural compounds.
Learn More:
Are you developing new or improved products, or thinking of applying for a patent? Did you know your research work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? To find out more, please check out our free online eligibility test.
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