Maryland Patent of the Month – November 2024
CellOptic, Inc. has unveiled a groundbreaking method in imaging science that promises to shatter conventional limits of optical resolution. Harnessing the power of Fresnel Incoherent Correlation Holography (FINCH) and advanced computational techniques, this innovation delivers images with resolution up to 10 times finer than standard optical imaging—redefining the possibilities for visualizing microscopic objects.
The method begins with recording holograms of an object using the FINCH system. Unlike traditional imaging, FINCH captures detailed interference patterns of light, yielding raw holograms that inherently double the resolution of conventional optical systems. These holograms are then processed computationally to reconstruct an image, serving as the foundation for a revolutionary iterative model-building algorithm.
What makes this approach transformative is the ability to refine reconstructed images into ultra-resolution outputs. By incorporating detailed knowledge of the point spread function (PSF) of the FINCH system, the algorithm iteratively compares, corrects, and enhances the model of the object. Each step improves the image’s fidelity, surpassing previous resolution limits to reveal structures at a nanoscopic scale.
This innovation combines the robustness of FINCH with the precision of computational modeling, enabling unparalleled imaging clarity. Unlike other super-resolution methods that rely on complex illumination setups or are constrained by traditional PSF limitations, CellOptic’s method is both versatile and accessible. It requires only modest imaging conditions and can be applied across a wide range of scientific fields, from biomedical research to materials science.
CellOptic’s ultra-resolution imaging method marks a paradigm shift in how we visualize the micro and nano worlds. By merging holography and computational refinement, it opens new frontiers in scientific discovery, providing researchers with a powerful tool to explore the unseen. This breakthrough stands as a testament to the transformative potential of innovation in optical technology.
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