Missouri Patent of the Month – October 2021

Unfortunately, many of us have experienced  the discomfort of a UTI (urinary tract infection). In fact, UTI’s are one of the most common infectious diseases in women. While men do experience them, they are far less common. Women who have experienced a UTI are also far more likely to have a recurring infection. With this high recurrence of UTIs, there is a rapidly growing resistance to antibiotics. As such, Fimbrion Therapeutics, Inc. has been working to develop a new treatment method, focusing on the use of C-mannoside compounds. 

The treatment created by Fimbrion uses C-mannoside compounds which have been found to inhibit FimH. FimH is a bacterial adhesin that helps bacteria such as Escherichia coli to bind to host cells and their receptors. Research has shown that the mannose-binding site FimH adhesin is critical for the colonization and invasion of the bacteria into the bladder epithelium. So stopping this binding should prevent infection from taking hold. The formulation uses mannose-containing small molecules – mannosides – to interfere with the adhesive function of FimH, preventing the bacteria from being able to stick to the walls of the bladder. Ultimately, this allows the body to naturally eliminate the infection on it’s own. Fimbrion is hopeful that this treatment will be able to expand to other bacterial infections while being minimally disruptive to the non-pathogenic, resident beneficial microbiota in your body.. 

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