New York Patent of the Month – March 2021

Some studies show that tumor infiltrating lymphocytes (TIL) can successfully mediate durable regression of metastatic melanoma. However, the same success has not been seen in other tumors as they have microenvironments capable of suppressing the TIL activity. Genetically altering the lymphocytes to recognize molecular targets on the tumors have helped to achieve regression in hematologic tumors. Unfortunately, a marker and molecule combination has not been identified in all solid tumors. Intima Bioscience, Inc. has developed a procedure to target gastrointestinal tumors with genetically modified TIL.

Lymphocytes are white blood cells that are also one of the body’s main types of immune cells. TIL are capable of infiltrating a tumor, though their access may be restricted. The TIL are taken from a donor and subjected to genetic modification using a CRISPR system. The TIL have been engineered to disrupt a specific gene so that Cytokine Inducible SH2 Containing Protein (CISH) protein function is suppressed. CISH controls T cell receptor (TCR) signaling. This modification allows TIL to target and infiltrate the tumor. The TIL are now functional for the targeted demise of the tumor.

About Intima Bioscience, Inc.

Intima Bioscience is a clinical stage gene and cell therapy company focused on curative intent in solid tumor cancer. They are in the clinical trial phase at the University of Minnesota for their study of Metastatic Gastrointestinal Cancers Treated with tumor infiltrating lymphocytes.

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