Pennsylvania Patent of the Month – April 2025
Marinus Pharmaceuticals has secured a new U.S. patent for its epilepsy drug ganaxolone, advancing treatment options for patients with a rare genetic disorder. The patent could expand the drug’s use to a broader patient population with limited therapeutic alternatives.
The patent, U.S. Patent No. 12,268,696, is titled “Ganaxolone for use in treating tuberous sclerosis complex and seizure disorders.” It covers methods of treating tuberous sclerosis complex (TSC) and related seizure disorders using ganaxolone or its pharmaceutically acceptable salts.
A Targeted Dosing Strategy
The invention includes a detailed dosing regimen, starting at 150 milligrams per day and increasing weekly to a maintenance dose of up to 1800 milligrams per day. This structured approach is designed to balance safety and effectiveness, especially for patients sensitive to neurological side effects.
Real-World Need and Market Potential
Tuberous sclerosis complex affects multiple organ systems and often causes drug-resistant seizures. Existing treatments can be inconsistent or poorly tolerated. Marinus’s patented use of ganaxolone addresses these challenges with a new mechanism of action and a flexible dosing schedule.
Strategic Milestone for Marinus
This patent strengthens Marinus’s intellectual property position in the neurology space. It also supports continued research and development aimed at expanding therapeutic uses for ganaxolone.
Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.
Who We Are:
Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.
Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at www.swansonreed.com/webinars or contact your usual Swanson Reed representative.
