Fort Lauderdale, Florida Patent of the Year – 2024/2025
Advantage Therapeutics Inc. has been awarded the 2024/2025 Patent of the Year for its novel approach to Alzheimer’s disease treatment. Their invention, detailed in U.S. Patent No. 11857568, titled ‘Treatment and prevention of Alzheimer’s disease (AD)’, utilizes an aluminum salt to target and prevent dementias associated with β-amyloid deposition, a hallmark of Alzheimer’s.
This patent underpins ADvantage’s lead candidate, AD04™, a subcutaneous injectable therapy currently in Phase 2b clinical trials across Europe. Unlike traditional treatments focusing solely on amyloid plaques, AD04™ modulates lipid metabolism in the hippocampus, aiming to restore protein expression levels akin to those in younger individuals. This multifaceted mechanism offers both immediate symptomatic relief and long-term disease modification.
AD04™ has demonstrated a favorable safety profile, notably avoiding adverse events like ARIA-E/H, common in other Alzheimer’s treatments. Its immunomodulatory properties stimulate and regulate the immune system, potentially reducing Alzheimer’s pathology without the side effects associated with other therapies.
The ongoing clinical trials aim to confirm AD04™’s efficacy and safety in patients with mild Alzheimer’s disease. If successful, this therapy could represent a significant advancement in Alzheimer’s treatment, offering hope to millions affected by this debilitating condition.