Richmond, Kentucky Patent of the Year – 2024/2025
Eastern Kentucky University has been awarded the 2024/2025 Patent of the Year for its groundbreaking advancement in targeted cancer therapy. Their invention, detailed in U.S. Patent No. 12152089, titled ‘LHRH-platinum conjugates for treating reproductive cancers’, introduces a novel compound that combines a hormone-targeting peptide with a platinum-based chemotherapy agent to selectively attack reproductive cancer cells.
This innovative approach links luteinizing hormone-releasing hormone (LHRH) to activated cisplatin using a malonate linker. The resulting conjugate specifically targets tumor cells expressing LHRH receptors, common in aggressive reproductive cancers. By directing the chemotherapy agent precisely to cancer cells, this method aims to enhance treatment efficacy while minimizing damage to healthy tissues.
Preclinical studies have demonstrated that this LHRH-platinum conjugate effectively inhibits tumor growth, particularly in late-stage and recurrent cancers. The targeted delivery system not only improves the potency of the chemotherapy but also reduces the debilitating side effects often associated with traditional treatments. This advancement holds promise for improving patient outcomes and quality of life.
Eastern Kentucky University’s development represents a significant step forward in personalized cancer treatment. By harnessing the specificity of hormone-receptor interactions, this patent could lead to more effective and less toxic therapies for patients battling reproductive cancers.
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