Toms River, New Jersey Patent of the Year – 2024/2025
Taran Therapeutics, Inc. has been awarded the 2024/2025 Patent of the Year for their breakthrough in treating chronic myelomonocytic leukemia (CMML). Their invention, detailed in U.S. Patent Application No. 20240309079, titled ‘Combination treatment of chronic myelomonocytic leukemia in patients with RAS pathway mutations’, offers a novel approach to combat this aggressive cancer.
CMML, a rare and challenging form of leukemia, often presents with mutations in the RAS signaling pathway, including NRAS, KRAS, and CBL genes. These mutations are associated with poor prognosis and resistance to standard treatments. Taran Therapeutics’ innovative method involves identifying these RAS pathway mutations in tumor cells and administering a combination therapy.
The proposed treatment includes an anti-hGM-CSF antibody, such as lenzilumab, which targets a specific cytokine involved in leukemia cell proliferation. When combined with a hypomethylating agent like azacitidine, this therapy has shown promising results. Clinical data indicate that this combination can achieve a complete or partial response rate of 50-90%, significantly higher than the 10-17% response rate seen with hypomethylating agents alone.
This dual-targeted approach represents a significant advancement in personalized medicine for CMML patients, offering hope for more effective treatments and improved outcomes in this challenging disease.
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