High Point, North Carolina Patent of the Year – 2024/2025
VTV Therapeutics LLC has been awarded the 2024/2025 Patent of the Year for its groundbreaking work in pharmaceutical chemistry. Their invention, detailed in U.S. Patent No. 11883383, titled ‘Pharmaceutically acceptable salts of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine’, introduces a novel class of compounds aimed at treating diseases mediated by the receptor for advanced glycation end products (RAGE).
This innovation focuses on developing stable, pharmaceutically acceptable salts of a specific compound known to inhibit RAGE. By creating these salts, vTv Therapeutics enhances the compound’s solubility and bioavailability, potentially improving its effectiveness as a therapeutic agent.
RAGE is implicated in various chronic conditions, including diabetes-related complications, Alzheimer’s disease, and certain cancers. By targeting this receptor, the new compounds could offer a versatile approach to managing these diseases.
The patent outlines methods for synthesizing these salts and demonstrates their potential in preclinical models. This advancement not only represents a significant step in drug development but also opens avenues for future research into RAGE-related therapies.
With this patent, vTv Therapeutics solidifies its position at the forefront of pharmaceutical innovation, offering hope for more effective treatments for complex diseases.