South Carolina Patent of the Month – March 2021

Studies have found that hyperglycemia increases the permeability of the blood brain barrier (BBB). Increased permeability can lead to cognitive dysfunctions as the brain is more readily exposed to foreign particles. Hyperglycemia has also been found to be accompanied by a reduced nitric oxide (NO) bioavailability. MUSC Foundation For Research Development has developed a method of treating these autoimmune diseases with S-nitrosoglutathione (GSNO).

Their method revolves around the concept of using GSNO to regulates BBB permeability. Reduced NO availability seems to impair the remodeling of vasculature which makes up the BBB and affects the permeability. GSNO and a derivative are both seen to contain reservoirs of NO. So MUSC Foundation has created a method of administering GSNO, increasing NO bioavailability and correcting the BBB permeability. Restoring the BBB can decrease neurological inflammation and brain edemas, improve microvessel structure, and ultimately improve cognitive function. The GSNO can be administered orally and the derivative could be administered in a few different ways, including orally or through an IV. The combined effects could improve the quality of life for many people facing hyperglycemia or similar diseases.

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