South Carolina Patent of the Month – May 2021
Scaffold-based tissue engineering approaches have largely focused on the use of 3D microenvironments to grow cardiac tissue. These scaffolds are lacking some important components including the chemical and biological properties of native extracellular environments of the myocardium. The alternative – which is scaffold-free 3D cardiac spheroids are prepared by seeding cardiomyocytes into agarose microwells. This method does produce improved cardiac function but formation is not as controlled and can ultimately produce unsynchronized contractions. Musc Foundation for Research Development has designed a new method to develop cardiac tissues containing semiconductor nanomaterials.
Their method involves seeding a substrate in an agarose gel with a cell suspension as well as semiconductor nanomaterial, creating a cell culture. The cell culture will then be electrically stimulated periodically using nanoscale semiconductors.. The cardiomyocytes can be grown in a controlled formation using scaffolding. This method brings the best of both traditional methods, and introduces electrical stimulation to produce the most functional synthesized tissue.
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