Bioreactors for Reparative Medicine (R43/R44)

Incentive Type: Grant Program
Medical, Health & Safety, Technology
Eligible Sector:
Financial Incentive
Time Period:
FY 2015
Governing Body: National Institutes of Health
What’s it worth?: $15,975,000

The Bioreactors for Reparative Medicine program is an effort to encourage small businesses to develop biomimetic culture systems with the ability to control cellular and 3-dimensional organ microenvironment and use unique physiological dynamics of heart, lung, and blood tissues. Funds are awarded to proposals that develop or use good laboratory practices and standards for pre-clinical research. Research examples include but are not excluded to:

  • Bioreactors that incorporate biomarkers and probes to efficiently and effectively detect and measure cellular processes during tissue growth, remodeling, and stabilization
  • Efforts incorporating microparticle materials to significantly reduce the expense in growing 3D cell aggregates
  • Systems integrating controlled mechanical and electrical loading without compromise to sterility conditions
  • Devices that robustly couple natural and/or artificial polymer synthesis to material formation and function for additive 3D tissue printing

A more complete list of examples can be found on the website.

These games should be designed to train, educate, and encourage behavioral changes. Funds typically do not exceed $225,000 for Phase I projects and $750,000 for Phase II projects. Applicants are encourage to contact the NIH program officials before proposing anything in excess of the guidelines. All applicants must meet the following criteria:

  • Applicant must be an organized for-profit organization located within the U.S. and operating in the U.S.
  • Is in the legal form of an:

– Individual proprietorship
– Partnership
– Limited liability company
– Corporation
– Joint venture
– Association
– Trust or cooperative

  • Must be less than 50% foreign participation
  • Be more than 50% directly owned and controlled by one or more individuals who are U.S. citizens
  • SBIR must be more than 50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these.
  • Be a joint venture
  • Does not have more than 500 employees

Application packets may be obtained from the website and must be complete and submitted before the deadline. Applicants must registered with:

  • Dun and Bradstreet Universal Number System (DUNS)
  • System for Award Management (SAM)
  • SBA Company Registry
  • eRA Commons

This program does not have any cost sharing requirements. Applications may include a Letter of Intent and must include:

  • SF424 Cover
  • SF424 Project Performance Site Locations
  • SF424 Other Project Information
  • SBA Company registry
  • STTR Application Certification
  • SF424 Senior/Key Personnel Expanded Profile
  • Budget
  • Cover Page Supplement
  • Research Plan
  • Appendix

Applications must be complete and received before the deadline.