Bioreactors for Reparative Medicine (R43/R44)

Bioreactors for Reparative Medicine (R43/R44)

The Bioreactors for Reparative Medicine program is an effort to encourage small businesses to develop biomimetic culture systems with the ability to control cellular and 3-dimensional organ microenvironment and use unique physiological dynamics of heart, lung, and blood tissues. Funds are awarded to proposals that develop or use good laboratory practices and standards for pre-clinical research. Research examples include but are not excluded to:

• Bioreactors that incorporate biomarkers and probes to efficiently and effectively detect and measure cellular processes during tissue growth, remodeling, and stabilization
• Efforts incorporating microparticle materials to significantly reduce the expense in growing 3D cell aggregates
• Systems integrating controlled mechanical and electrical loading without compromise to sterility conditions
• Devices that robustly couple natural and/or artificial polymer synthesis to material formation and function for additive 3D tissue printing

A more complete list of examples can be found on the NIH.gov website.

These games should be designed to train, educate, and encourage behavioral changes. Funds typically do not exceed $225,000 for Phase I projects and $750,000 for Phase II projects. Applicants are encourage to contact the NIH program officials before proposing anything in excess of the guidelines. All applicants must meet the following criteria:

• Applicant must be an organized for-profit organization located within the U.S. and operating in the U.S.
• Is in the legal form of an:

– Individual proprietorship
– Partnership
– Limited liability company
– Corporation
– Joint venture
– Association
– Trust or cooperative

• Must be less than 50% foreign participation
• Be more than 50% directly owned and controlled by one or more individuals who are U.S. citizens
• SBIR must be more than 50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these.
• Be a joint venture
• Does not have more than 500 employees

Application packets may be obtained from the Grants.gov website and must be complete and submitted before the deadline. Applicants must registered with:

• Dun and Bradstreet Universal Number System (DUNS)
• System for Award Management (SAM)
• SBA Company Registry
• eRA Commons
• Grants.gov

This program does not have any cost sharing requirements. Applications may include a Letter of Intent and must include:

• SF424 Cover
• SF424 Project Performance Site Locations
• SF424 Other Project Information
• SBA Company registry
• STTR Application Certification
• SF424 Senior/Key Personnel Expanded Profile
• Budget
• Cover Page Supplement
• Research Plan
• Appendix

Applications must be complete and received before the deadline.