Hawaii Patent of the Month – October 2021

TruTag Technologies, Inc. is the leading developer of silica tags for pharma & nutra, secure labels & docs & drug delivery. In some cases, molecular labels have been used to determine the identity and presence of an analyte as it reacts with a probe.These labels, however, can affect the properties of the analytes and result in undesirable interactions. There have been achievements in label-free detection but it is time consuming and expensive. They rely on fluorophores which are expensive and take a long time to attach to an analyte. Other methods use resonance energy of plasmonic waves but require coherent light sources. Recently, TruTag has developed an alternative labeling system which uses optical thickness measurements of the biosensor.

A reader is configured to immobilize the tag on the substrate surface. This tag is bound to a probe and has a series of pores capable of producing an index of refraction. The system detects an analyte suspected of being present in a sample. The reader exposes the optical tag to electromagnetic radiation to generate a sample spectral signature which is a function of parameters including the thickness of the optical tag and whether the analyte is coupled to the probe. The sample spectral signature is then compared to a reference signature to determine if the analyte is present. TruTag believes this can be used in nearly any industry, to turn every product into a data point, tracing from the point of origin to the consumer end point.

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