Massachusetts Patent of the Month – February 2022

Certain forms of bacteria can be beneficial and used to suppress the growth of pathogenic bacteria. AOBiome, LLC has been working with Ammonia Oxidizing Bacteria (AOB) to treat a variety of skin disorders caused by these pathogenic bacterias. 

They have formulated a compound with AOB which can be applied topically without irritating skin. This research is based on the relationship between various bacteria in our microbiome. When ammonia secretes through the skin, ammonia oxidizing bacteria can break it down into nitric oxide and nitrite. The first component has anti-inflammatory properties and the second has anti-infective properties. Because of this process, AOB can result in targeted, topical anti-inflammatory and anti-infection.

Our body responds to some bacteria in ways that are uncomfortable for us. A little bacteria on the face can lead to acne with inflamed bumps along the skin. Reactions to other bacteria can lead to redness and itchiness. Applying AOB can mitigate these immune responses without impairing the body’s response to the pathogenic bacteria.

The company has conducted six different Phase 2 clinical programs and even more pre-clinical programs since 2016. All of these programs have shown great tolerability and effectiveness so far.

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