New York Patent of the Month – April 2024
Spheryx, Inc. is building particle characterization technology for use in nearly any industry – from water quality to semiconductor manufacturing. The company’s Total Holographic Characterization® has recently been granted a patent and aims to deliver solutions that provide a new window into suspensions at the sub-visible level.
The technology brings unprecedented precision and efficiency to the analysis of particles in fluid mediums. This innovative approach involves dispersing a mixture of known and unknown particles within a fluid medium, then flowing this mixture through an observation volume of a holographic microscope.
By generating holographic images based on video microscopy, Spheryx captures the intricate details of particle interactions within the observation volume. The first holographic image is analyzed for regions of interest corresponding to specific particles. Through a series of steps involving normalization and fitting to light scattering theory, the method accurately characterizes the refractive index of the particles, shedding light on their properties.
What sets Spheryx’s method apart is its applicability to a wide range of particles, including porous and irregularly shaped ones. Traditionally, holographic microscopy was limited to analyzing spherical particles, but Spheryx’s approach extends its capabilities to materials with diverse shapes and compositions.
One remarkable aspect of Spheryx’s method is its ability to compare refractive indices between different particles, enabling the characterization of entire groups of particles based on these comparisons. This holistic approach to particle analysis opens up new avenues for understanding complex materials and their behavior in various environments.
The applications of this technology are vast, spanning industries from pharmaceuticals to semiconductor processing. With its ability to provide precise measurements and insights into particle properties, Spheryx’s method promises to drive innovation and advance research in countless fields.
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