Nicox SA Announces Phase 2b Results

Nicox SA has recently released the results from their Mississippi Phase 2b clinical trials. This international ophthalmology company has dedicated themselves to the development of treatments to help maintain vision and improve ocular health. 

One of their products in development is the once-daily dosed NCX 4251 – a fluticasone propionate ophthalmic suspension 0.1%. This product was trialed against placebos in patients with acute exacerbations of blepharitis. 

Blepharitis is a condition leading to red, swollen, itchy eyelids which can lead to more serious conditions including conjunctivitis.

The primary measure of this Phase 2b trial looked at the proportion of patients achieving complete cure in all three hallmark signs and symptoms of blepharitis, eyelid redness, debris, and discomfort by day 15. Two separate secondary outcome measures were identified as signs and symptoms of dry eye. 

The Results

The trial did not meet either primary or secondary efficacy endpoints. However, a signal of NCX 4251’s potential efficacy was seen in the trial. NCX 4251 at 0.1% showed a numerical improvement over a placebo outcome for the primary measure. It also showed a statistically significant difference against placebo surrounding the change from baseline in certain symptoms. They intend to further their data analysis to decide which key signs and symptoms should be the focus for future development.

It was also found safe and well tolerated over the 14 day treatment period, with no adverse or serious side events. 

Are you developing new software for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

Who We Are:

Swanson Reed is one of the U.S.’ largest Specialist R&D tax advisory firms. We manage all facets of the R&D tax credit program, from claim preparation and audit compliance to claim disputes.

Swanson Reed regularly hosts free webinars and provides free IRS CE and CPE credits for CPAs. For more information please visit us at or contact your usual Swanson Reed representative.

Recent Posts