Seqirus to Begin Dedicated sa-mRNA Program

Seqirus is one of the world’s largest influenza vaccine companies, working to develop new vaccines every single year. Recently, this New Jersey-based company has announced plans to expand and accelerate their capabilities to develop next-gen self amplifying mRNA (sa-mRNA) vaccines. To achieve this goal, they will create a dedicated sa-mRNA program.

Last year the FDA green lit Audenz for the protection against influenza A (H5N1) in the event of a pandemic and won approval for Fluad Quadrivalent just three weeks later. This is the first and only quadrivalent adjuvanted flu vaccine to help protect adults over 65 years of age. Shortly after, their Flucelvax Quadrivalent was approved for a broader set of patients (ages two and up). 

mRNA has been a notably well researched topic, but its implication and authorization of use in vaccines came with research done to fight COVID-19. mRNA based vaccines work by providing instructions to cells to make a protein that stimulates the immune response to fight future infections. Seqirus’ sa-mRNA tech also teaches the body to replicate mRNA, taking it a step further and amplifying the amount of protein made. This development suggests that the future of vaccines may be smaller doses, less negative reaction, and higher efficacy. 

Seqirus is already developing multiple sa-mRNA-based influenza vaccine candidates with promising preclinical results but are hoping their dedicated sa-mRNA program will speed this along. If all goes well, they may even have clinical trials beginning for both seasonal and pandemic influenza vaccine candidates in the second half of 2022.

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