Tennessee Patent of the Month – July 2021

Healing of an injury is typically divided into three phases – the inflammatory, proliferative, and maturation/remodeling phase. A complication in any phase can cause issues or failure in the healing process. The ease of healing depends on the type of tissue that is injured, with tendons and ligaments being particularly challenging. NellOne Therapeutics, Inc. has developed a tissue regeneration method using NELL1.

The neural epidermal growth-factor-like 1 (NELL1) is a peptide capable of promoting the maturation of a progenitor cell, further enhancing proliferation of fibroblast cells, and eventually promoting the healing of a wound. It is naturally produced in high amounts during fetal development. Fetal time is the only naturally regenerative phase of human life, and the only time when the body experiences scarless healing and natural regeneration. NellOne Therapeutics is developing a treatment using NELL1 to reduce inflammation and promote tissue growth. They have recently tested NELL1, using horse NELL1 proteins on horse wounds. The results showed no adverse effects and showed faster healing compared to control wounds. NellOne Therapeutics intends to continue along the pipeline, bringing a treatment option to the commercial space.

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