Connecticut Patent of the Month – April 2022

Grover’s disease – or Transient Acantholytic Dermatosis – is a rare, temporary skin condition. The symptoms present as sudden red, raised, blistery, and sometimes very itchy spots that form around the middle of the body. This disease comes and goes with sudden onset and no warning. While steroid creams provide some temporary relief, there is no cure.

Excessive sun exposure, sweating, and heat can induce more itchy spots leading to most afflicted individuals to limit their time spent in the sun or exercising.

Recent research has shown that photo-therapy might be a more effective treatment with longer effects. Controlled exposure to natural sunlight or UV light has shown promising results as it increases T-cell activation. Unfortunately this comes with the conundrum that excessive exposure can worsen the condition.

TCellerate, LLC has designed a treatment device that delivers this photo-therapy in a controlled manner to ensure treatment is effective without passing into overexposure. Their photo-therapy device applies blue LED light onto the patient’s skin. While the treatment time  and intensity can be adjusted, the patient needs to absorb between 500 and 3,000 watt-minutes of radiation to reduce or even eliminate the rash. The treatment can range from 10 minutes to an hour, with no upper limit on time. 

The device looks similar to a tanning bed, with LED lights on the upper portion. The patient lays in the bed on their back to expose the front of their body to phototherapy. They can turn around to expose their back. Treatment can be applied multiple times a week, all dependent on the severity of the rash. This treatment option proves more effective than steroid treatments, working to eliminate the rash rather than reduce the itchiness. Grover’s Disease is not fatal, but living with it can be debilitating. TCellular is set on returning control to patients so that they may enjoy their life to the fullest.

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