Georgia Patent of the Month – July 2020
Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers and 60% of these have wild-type epidermal growth factor receptor (EGFR) mutations. EGFR tyrosine kinase inhibitors (TKIs) have been effective for treatment of NSCLCs with EGFR mutations, but not those with wild-type mutations.
Emory University, in Atlanta – alongside The University of North Carolina at Chapel Hill – has developed a method for treating cancer with a combination of MER gene TKIs and an EGFR inhibitor. As part of this patent, the university has also developed the pharmaceutical composition of the treatment in oral dosage form (e.g. as a tablet or capsule).
The dual inhibitor compounds address a range of tumors, including:
- non-small cell lung cancer, glioblastoma, breast, head or neck, colon, gastric, or bladder cancer tumors,
- malignant primary tumors,
- metastatic secondary tumors, and/or
- metastatic non-small cell lung cancer tumors in the brain.
This method has been found to inhibit tumor growth, reduce tumor size, and/or reduce the number of tumors. This method has, in some instances, killed tumor cells with less harm to healthy cells than other options (e.g. chemotherapy). Further, it has affected cells that have otherwise been resistant to other treatments (e.g. metastatic lung cancer tumors in the brain).
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