Missouri Patent of the Month – January 2024
Mo-Sci Corp. was founded by Dr. Delbert Day in 1985 to supply glass and ceramic products for niche market applications. The company has since expanded to address the specific and niche glass needs of a range of industries, including that of the healthcare industry.
Within this mission, the company has recently been granted a patent for an advanced resorbable tissue graft scaffold material. This innovative biomaterial sets a new standard by combining a myriad of features to enhance bone regeneration while addressing the limitations of existing graft materials.
At its core, the tissue graft scaffold is a three-dimensional, flexible, and porous structure composed of overlapping and interlinking polymer-free, bioactive glass and ceramic fibers. These fibers, meticulously chosen from materials like calcium phosphate, hydroxyapatite, and bioactive glass, form the scaffold’s foundation, providing structural integrity and mimicking the natural bone environment.
What sets Mo-Sci’s invention apart is the incorporation of bioactive, resorbable glass or ceramic beads strategically distributed throughout the scaffold. These beads play a pivotal role, contributing from 60 to 95 weight percent of the tissue graft material. The beads, whether solid or hollow with inner core volumes, further diversify the scaffold’s functionality. Hollow beads, for instance, can be filled with medicines, antibiotics, or other supplements, adding a therapeutic dimension to the graft.
The versatility of the invention is showcased through variations in bead properties—ranging from solid to porous and diameters from 30 microns to 3 millimeters. This adaptability allows tailoring the graft for specific applications, from soft tissue treatments to hard tissue applications.
Mo-Sci’s resorbable tissue graft scaffold material offers a solution to the challenges posed by traditional autograft and allograft devices. With a composition entirely controlled and manipulated, the synthetic scaffold eliminates the risk of disease transmission and offers consistent quality.
The invention’s broad application is further emphasized by its flexibility in bulk density, accommodating diverse clinical scenarios. Whether for soft tissue applications with a density between 0.1 g/cc and 0.5 g/cc or hard tissue applications with a density between 0.8 g/cc and 1.5 g/cc, Mo-Sci’s tissue graft scaffold material excels.
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