Missouri Patent of the Month – November 2023

Xeragenx, LLC, a biotech firm focused on recombinant human Intrinsic Factor (rh-IF), is altering the landscape of diabetes treatment with an innovative method that uses IF to amplify the effectiveness of a pharmaceutical composition. This method revolves around administering a compound of IF combined with a conjugate containing B12 and a glucagon-like peptide-1 (GLP-1) receptor agonist. The result? A groundbreaking approach for lowering blood glucose levels.

Diabetes mellitus is a chronic metabolic disorder caused by a deficiency of insulin hormone. GLP-1 receptor agonists have garnered interest in the treatment of Diabetes based on its impacts on managing blood glucose levels. The composition developed by Xeragenx links B12 to a GLP-1 receptor using IF to effectively reduce or control blood glucose levels. This works because IF transports the B12 to receptors in the distal small intestine for faster absorption into the body.

As research continues and pharmaceutical advancements push the boundaries, Xeragenx’s innovation represents a crucial step in redefining diabetes management. The potential application of IF to enhance drug delivery, protein stability, oral absorption, and precision liver targeting unveils an exciting chapter in the realm of medical therapeutics. The development might well usher in a new era of precision medicine, improving existing diagnostic tests and introducing newer, more effective ones.

Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.

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