New York Patent of the Month – October 2023

Gameto, Inc. is a pioneering biotechnology company with a mission to revolutionize the traditional fertility process. Their primary goal is to develop innovative therapies that enhance the quality of life for women. In an often underserved therapeutic area, Gameto is committed to addressing the limited treatment options and complications to improve and modernize the entire female reproductive journey.

Gameto has established a platform for generating female reproductive cell lines. Their approach involves the strategic use of proprietary transcription factors to reprogram human induced pluripotent stem cells (hiPSCs) into engineered ovarian and endometrium cell lines. These engineered cells closely mimic the functions of natural endogenous cells, including the production and response to hormones.

One of the significant issues in the realm of female reproductive health is the inadequacy of current hormone replacement methods. Traditional hormone replacement therapies provide hormones at fixed daily doses, failing to deliver personalized and physiologically-based hormone delivery. Recognizing this challenge, Gameto has introduced an innovative implant designed to combat ovarian decline effectively.

This implant consists of an engineered ovarian support cell, an extracellular matrix substrate, and a delivery apparatus. These components work synergistically to provide a more tailored and precise approach to hormone replacement, offering a potential breakthrough in addressing ovarian decline.

Gameto’s dedicated team of cellular engineers is harnessing this platform to advance a diverse portfolio of cellular therapeutics specifically targeted at addressing various female reproductive diseases. Their flagship program, Fertilo, focuses on improving in vitro fertilization (IVF) and egg freezing, with the aim of streamlining the processes, enhancing safety, and increasing effectiveness. Additionally, Gameto’s platform enables the development of an organoid of the female reproductive system, known as Deovo, as well as a cell-based therapeutic called Ameno, which seeks to mitigate the health consequences associated with primary ovarian insufficiency and menopause.

Gameto’s commitment to scientific excellence and innovative solutions positions them at the forefront of reshaping female reproductive healthcare, with the potential to make a significant impact on the lives of countless women.

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