Hawaii Patent of the Month – May 2021

Hydrogels are made of 3D hydrophilic polymer structures with lots of water. Polysaccharide hydrogels have a good microenvironment or cell growth, making them ideal for wound dressing, regenerative medicine, and drug delivery. OceanIt Laboratories, Inc. has developed a new hydrogel based on chitosan and hyaluronic acid.

Chitosan or hyaluronic acid hydrogel compositions are a more efficient hydrogel for wound treatment as it requires a lower level of care, is more therapeutically effective, and is less expensive to produce. OceanIt’s method forms two biopolymers (chitosan and hyaluronic acid) into a single hydrogel. First they dissolve an amount of chitosan by adjusting the pH. Then they do the same with a hyaluronan in a separate container. Carbodiimide activate reagents are then added to the hyaluronan solution, and the two components are mixed together, forming the hydrogel. This hydrogel is transparent, sterilized, and made of non-animal products to reduce allergic reaction. On application, it conforms to the wound surface geometry and can stimulate immune response and cell migration to help close the wound.

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