Indiana Patent of the Month – January 2024

Welcome to the future of particle analysis with Miftek Corporation‘s revolutionary flow cytometer. This cutting-edge invention takes microvesicle observation to new heights, offering a breakthrough in quantitative measurement platforms.

The flow cytometer is designed with precision and innovation, featuring a flow chamber equipped with a flow channel for seamless microvesicle flow through a sensing region. What sets this invention apart is the irradiation optical system that bathes the microvesicle target in incident light. This incident light, configured as an irradiation spot, allows for unparalleled observation accuracy.

An optical disperser then spectrally disperses resultant light, generating multiple light beams of different wavelengths. The brilliance of this invention lies in its multiple photodetectors, each receiving a specific light beam and providing corresponding resultant-light signals. This enables a meticulous analysis of microvesicles based on their spectral characteristics.

To enhance efficiency, a spot-traversal system induces motion of the irradiation spot across the microvesicle target in the sensing region. This dynamic approach ensures comprehensive coverage and detailed observation, contributing to the precision of the quantitative measurement platform.

Miftek’s flow cytometer goes beyond mere observation; it introduces intelligent features. A memory, photosensor, gating circuit, and processor work in harmony. The photosensor captures a portion of the resultant light, generating a pre-gating signal. The gating circuit, driven by this signal, determines the measurement time period, allowing the processor to store data representing resultant-light signals during specific measurement intervals.

The invention’s brilliance extends to its ability to determine the identity of microvesicle targets. A memory stores spectral signatures and associated identities, while the processor matches the spectral signature of the observed microvesicle against this database, providing a clear identification.

The use of photon detectors and photosensitive integrated-circuit components further elevates the accuracy, ensuring that each photon is accounted for without averaging. Additionally, the incorporation of a concave toroidal grating in the optical disperser enhances the precision of spectral dispersion.

Miftek Corporation’s flow cytometer brings a new era of quantitative microvesicle measurement. This invention not only observes microvesicles but also introduces intelligent and dynamic features for a comprehensive and accurate analysis. 

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