New York Patent of the Month – December 2023

In the realm of neuroscience and therapeutic interventions, Ovid Therapeutics, Inc. has embarked on a groundbreaking journey with their patented methods and compositions for the treatment of epileptic disorders. The patent, a testament to their innovative strides, delves into the intricate landscape of managing epilepsy, a condition affecting millions worldwide.

Epileptic disorders are known for their complexity, often requiring a multifaceted approach to treatment. Ovid believes their approach – OV329 – is significantly more potent than prior GABA-AT inhibitors which may confer seizure reduction efficacy, enhanced safety, and lower dosing.

Ovid’s approach uses a next-generation GABA-aminotransferase (GABA-AT) inhibitor to treat even the most rare and treatment-resistant forms of epilepsy and seizures. The mechanism of action targets GABA – the main inhibitory neurotransmitter in the brain. Low levels of GABA in the brain have been linked to neuronal hyperexcitability, which can lead to seizures. GABA is readily catabolized by the enzyme, GABA-AT. By targeting and inhibiting this enzyme, GABA catabolization can be limited and those who have low levels are protected from the levels dropping even lower. In this approach, those at risk of seizures as a result of low GABA levels are protected.

OV329 is currently in a Phase 1 study with healthy volunteers to evaluate the safety, pharmacokinetic profile and target engagement associated with single and repeated oral doses of OV329. The Phase 1 study will measure two potential biomarkers for target engagement via magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS). Ovid is also exploring acute treatment options with a potential IV formulation of OV329.

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