Rhode Island Patent of the Month – March 2024

EpiVax, Inc., an immunology technology company, is developing treatment regimes with regulatory t-cell epitopes to target immune-related disorders. Their innovative approach involves inducing regulatory T-cells to suppress immune responses in patients, offering new hope for conditions such as autoimmune diseases, allergies, and transplant-related disorders.

At the heart of this method lies a novel class of regulatory T-cell epitopes, referred to as “Tregitopes.” These Tregitopes, comprised of specific amino acid sequences, have shown remarkable efficacy in modulating the immune system’s response. By administering therapeutically effective amounts of Tregitope compositions to patients, EpiVax aims to harness the power of regulatory T-cells to dampen unwanted immune reactions.

The beauty of this approach lies in its specificity and precision. Unlike broad-based immune-depleting therapies that weaken the entire immune system, EpiVax’s method targets the underlying mechanisms of immune regulation, offering a more targeted and effective treatment option. This precision is crucial for minimizing side effects and maximizing therapeutic benefits.

The potential applications of EpiVax’s method are vast. From autoimmune diseases like type 1 diabetes and lupus to transplant-related disorders such as graft-versus-host disease, the ability to induce immune tolerance could transform the lives of millions of patients worldwide. Additionally, this method holds promise for mitigating allergic reactions, preventing immune rejection of biologic medicines, and combating immune responses to infectious diseases.

Central to EpiVax’s approach is the identification and utilization of regulatory T-cell epitopes contained within common proteins. These Tregitopes, carefully selected for their ability to activate regulatory T-cells, serve as the cornerstone of the therapeutic compositions developed by EpiVax. By leveraging these natural mechanisms of immune regulation, EpiVax aims to provide safer and more effective treatments for a wide range of immune-related disorders.

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