Massachusetts Patent of the Month – August 2025
A new patent has been granted to NFlection Therapeutics Inc. for a class of compounds designed to treat various skin disorders. The patent, U.S. Patent No. 12378240, titled ‘Naphthyridinone-aniline compounds for treatment of dermal disorders’, outlines a novel approach to addressing conditions like neurofibromatosis and other dermal diseases driven by an overactive RAS pathway.
A Targeted Approach to Skin Health
The invention introduces a series of naphthyridinone-aniline compounds. These compounds work as inhibitors of the MEK enzyme. MEK is a key part of the cellular pathway that can lead to tumor growth and other skin-related issues when overactivated. By targeting this specific enzyme, the compounds aim to address the root cause of these conditions.
The patent claims several uses for these compounds. They can be formulated into pharmaceutical compositions. The treatment methods described include topical, transdermal, and intralesional administration. This suggests a localized treatment that could reduce systemic side effects. The focus is on conditions such as neurofibromatosis type 1 and other rasopathies, which currently have limited treatment options.
This development could lead to new therapies for a range of dermal disorders. It represents a significant step forward in targeted dermatology. The compounds offer a promising new path for patients with these often-disfiguring conditions.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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