New Jersey Patent of the Month – October 2025
A groundbreaking oncology patent outlines a new targeted approach to cancer therapy. This innovation focuses on creating highly specific drugs designed to combat ROR1-expressing tumors. U.S. Patent No. RE50631, titled ‘ROR1 antibody immunoconjugates’, details a potent new class of Antibody-Drug Conjugates (ADCs). The technology provides a precision-guided system for delivering powerful chemotherapy directly to malignant cells.
Precision Cancer Targeting
This therapy uses a two-part system. The first part is an antibody that specifically hunts down the ROR1 protein found on many cancer cell surfaces. The second part is a potent cytotoxic drug. The antibody acts as a microscopic “smart bomb”. It attaches only to the cancerous cells. Once attached, it releases its toxic payload inside the tumor. This mechanism spares healthy cells from the destructive effects of traditional chemotherapy.
Potential Real-World Impact
The patented technology originated with VelosBio Inc. . It is a major step in the fight against difficult-to-treat hematologic cancers. This treatment is particularly useful against lymphomas. These include Diffuse Large B-cell Lymphoma (DLBCL) and Mantle Cell Lymphoma (MCL). The patent also covers combining the ADC with other established cancer drugs. This strategy could improve treatment outcomes for patients globally.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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