California Patent of the Month – January 2025
GRAIL has pioneered a groundbreaking method in early cancer detection, leveraging cutting-edge machine learning and genomic sequencing. This revolutionary approach utilizes a proprietary classifier trained on vast genomic datasets to accurately categorize a patient’s cancer type from a simple blood sample. By analyzing nucleic acid fragments and applying advanced dimensionality reduction techniques, GRAIL’s system enhances computational efficiency while maintaining high diagnostic accuracy.
The process involves extracting DNA fragments from blood plasma and mapping them onto the human genome. A classifier, refined through iterative training and resampling, discerns subtle patterns that differentiate cancerous from non-cancerous signals. This method enables multi-cancer detection across numerous cancer types, including lung, breast, pancreatic, and colorectal cancers, among others. Unlike traditional diagnostics that often rely on tissue biopsies or symptomatic detection, GRAIL’s technology aims to identify cancer at its earliest and most treatable stages.
What sets GRAIL apart is its integration of methylation analysis, further increasing precision by examining chemical modifications to DNA that are indicative of cancer presence. The system not only detects cancer but also provides insights into tumor origin, guiding clinicians toward more informed treatment decisions. Moreover, its ability to scale through cloud-based computing ensures accessibility for widespread clinical application.
This breakthrough represents a paradigm shift in oncology, offering hope for a future where cancer can be detected non-invasively and treated proactively. GRAIL’s innovation is paving the way for earlier interventions, improved patient outcomes, and a redefined standard for cancer diagnostics.
Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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