Maryland Patent of the Month – October 2024
Innovative Cellular Therapeutics (ICT) has made a significant breakthrough in cancer treatment with its latest invention—a modified cell designed to overcome the challenges of treating solid tumors. This invention involves a novel combination of genetic sequences, each carefully selected for its potential to enhance cancer therapy.
The cell modification comprises a polynucleotide that includes a nuclear factor of activated T-cells (NFAT) promoter, a therapeutic agent, and a VHL-interaction domain from hypoxia-inducible factor 1-alpha (HIF1α). The NFAT promoter controls the expression of the therapeutic agent, ensuring it is activated in response to T-cell activation. This is crucial because activated T-cells play a key role in immune responses, particularly in the fight against cancer cells.
The therapeutic agent encoded by this cell is designed to target and disrupt the growth of cancer cells, while the VHL-interaction domain from HIF1α enhances the cell’s ability to function in low-oxygen environments, which are common in solid tumors. This dual mechanism of action—targeting tumor cells through T-cell activation and adapting to hypoxic conditions—provides a promising approach to solid tumor therapies, which have traditionally been more challenging to treat compared to blood cancers.
This breakthrough has the potential to revolutionize cancer treatment by enabling a more efficient and targeted immune response. It represents a step forward in the development of personalized cancer therapies, offering a precise way to address the complexities of solid tumors. With ICT’s innovative approach, the future of cancer treatment looks increasingly promising, particularly in improving outcomes for patients with difficult-to-treat cancers.
Are you developing new technology for an existing application? Did you know your development work could be eligible for the R&D Tax Credit and you can receive up to 14% back on your expenses? Even if your development isn’t successful your work may still qualify for R&D credits (i.e. you don’t need to have a patent to qualify). To find out more, please contact a Swanson Reed R&D Specialist today or check out our free online eligibility test.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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