Missouri Patent of the Month – September 2025
A new chemical purification process promises higher-grade active ingredients for advanced diagnostic tools. MediBeacon Inc. secured U.S. Patent No. 12428382 for a novel method to refine key chemical compounds. The patent, titled ‘Purification of substituted diaminopyrazine dicarboxylic acids’, describes a technique critical for pharmaceutical development. This streamlined process removes harmful impurities and residual solvents efficiently. High purity is essential for safety and efficacy in medical applications.
Revolutionizing Ingredient Purity
The innovation centers on a low-temperature, vacuum-driven distillation sequence. This method purifies a specific amino acid ester compound. The compound is a precursor to luminescent agents, often used for real-time physiologic monitoring. The proprietary process involves contacting the crude compound with a mixture of solvents, like ethyl acetate and isopropanol. Subsequent distillation steps under vacuum strip away contaminants. The technique maintains temperatures below 40∘C and cools the final mixture, preventing degradation. The strict control delivers purity levels exceeding 97%. This high standard is necessary for clinical use and manufacturing scale-up. It ensures better performance for MediBeacon’s pipeline products.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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