North Carolina Patent of the Month – September 2025
Biopharmaceutical company RENOVION INC. has secured a patent for a novel method to manufacture its drug candidate, ARINA-1. This new process aims to help patients with chronic inflammatory lung diseases. The invention stabilizes a therapeutic solution for conditions like cystic fibrosis and COPD.
A Novel Stabilization Method
The key innovation lies in a unique manufacturing environment. Glutathione, a natural antioxidant, is notoriously unstable in water-based solutions. This instability can reduce a drug’s effectiveness. Renovion’s patented method dissolves L-glutathione and other agents under a pure carbon dioxide atmosphere. The final product is sealed in a container with a carbon dioxide headspace. This technique prevents oxidation and preserves the drug’s potency.
Potential Impact on Lung Disease Treatment
This stable formulation could significantly improve outcomes for lung disease patients. The process is outlined in U.S. Patent No. 12419932, titled ‘Aqueous solution comprising a glutathione salt’. It enables a ready-to-use therapy that can effectively reduce lung inflammation. This breakthrough supports a more reliable treatment for millions suffering from debilitating respiratory conditions.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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