Ohio Patent of the Month – October 2025
A new U.S. patent marks a major step in the fight against advanced breast cancer. This innovation targets tumors that become resistant to standard hormone therapy. Sermonix Pharmaceuticals Inc. received U.S. Patent No. 12433866. Its focus is on using the drug lasofoxifene to treat aromatase-resistant, estrogen receptor-positive (ER+) cancer. This offers a potent, oral option for patients facing limited therapeutic choices.
Developing a New Weapon
Endocrine therapy is the main treatment for most breast cancers. Tumors often develop resistance over time. This frequently happens due to acquired ESR1 gene mutations. These mutations make the tumors unresponsive to traditional drugs like aromatase inhibitors. Lasofoxifene is an oral, next-generation Selective Estrogen Receptor Modulator (SERM). It works by directly targeting these problematic ESR1 mutations. Preclinical and clinical data suggest it may be more effective than current injectable standards. This novel approach restores drug sensitivity in resistant cancers.
Real-World Patient Impact
This patent protects a critical therapeutic strategy. The treatment could significantly improve outcomes for patients with metastatic disease. Lasofoxifene is conveniently administered as an oral pill. This contrasts sharply with current injectable treatments. The ease of use could enhance quality of life and adherence. This development represents a key advance in precision oncology. The patent title is ‘Lasofoxifene treatment of aromatase-resistant ER+ cancer’. Sermonix is moving this drug forward in Phase 3 clinical trials.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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