Roswell, Georgia Patent of the Year – 2024/2025
CorMatrix Cardiovascular Inc. has been awarded the 2024/2025 Patent of the Year for its groundbreaking innovation in cardiovascular tissue repair. Their invention, detailed in U.S. Patent No. 11865226, titled ‘Cardiovascular prostheses’, utilizes a novel biomaterial composed of poly(glycerol sebacate) (PGS), cerivastatin, and everolimus to modulate inflammation and promote healing in damaged heart tissue.
This patented prosthesis introduces particulate structures designed to increase the expression of Kruppel-like factor 2 (KLF-2), a gene that plays a critical role in vascular health. By enhancing KLF-2 expression, the device effectively reduces the production of inflammatory markers such as MCP-1 and CCR2, leading to a decrease in tissue inflammation and improved healing outcomes.
The innovation addresses a significant challenge in cardiovascular medicine: the body’s inflammatory response to implanted devices. Traditional prostheses can trigger adverse reactions, compromising their effectiveness. CorMatrix’s approach offers a biocompatible solution that not only supports tissue regeneration but also minimizes inflammation, potentially improving patient recovery and long-term outcomes.
This advancement exemplifies the ongoing evolution of biomaterials in medical applications, highlighting the potential for engineered solutions to enhance the body’s natural healing processes. As cardiovascular diseases remain a leading cause of mortality worldwide, innovations like this represent a promising step forward in patient care and medical technology.