West Virginia Patent of the Month – December 2025
A breakthrough in metabolic medicine is targeting the global rise of fatty liver disease with a precise molecular approach. Modulation Therapeutics, Inc. is advancing a new class of inhibitors designed to halt the progression of liver damage by regulating lipid metabolism. This innovation, detailed in U.S. Patent Application No. 20250381176, titled ‘Scd1 inhibitors for treating liver disease’, offers a specialized solution for conditions like non-alcoholic steatohepatitis (NASH).
Precision Targeting for Liver Health
The core of the technology focuses on inhibiting Stearoyl-CoA Desaturase 1 (SCD1). This enzyme plays a critical role in how the body synthesizes monounsaturated fatty acids. When SCD1 is overactive, it leads to excessive fat buildup and inflammation in liver tissues. By precisely blocking this enzyme, the new compounds help restore healthy metabolic balance. This targeted action reduces the dangerous accumulation of lipids that often triggers long-term organ scarring.
Impact on Global Healthcare
Liver diseases currently affect millions worldwide, yet few effective treatments exist to reverse early-stage damage. This invention provides a promising path for patients facing chronic inflammation and metabolic dysfunction. The therapeutic potential extends beyond simple fat reduction, as it addresses the underlying biological pathways of the disease. This development could significantly lower the need for invasive procedures or organ transplants in the future. With these potent inhibitors, the medical community gains a vital tool to combat the growing obesity-related health crisis.
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The Research & Experimentation Tax Credit (or R&D Tax Credit), is a general business tax credit under Internal Revenue Code section 41 for companies that incur research and development (R&D) costs in the United States. The credits are a tax incentive for performing qualified research in the United States, resulting in a credit to a tax return. For the first three years of R&D claims, 6% of the total qualified research expenses (QRE) form the gross credit. In the 4th year of claims and beyond, a base amount is calculated, and an adjusted expense line is multiplied times 14%. Click here to learn more.
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