Connecticut Patent of the Month – March 2025
Quantum-Si has launched a cutting-edge method for sequencing individual protein molecules, marking a significant step forward in proteomics and biomedical research. The technique allows for real-time decoding of proteins, one amino acid at a time.
How It Works
The process begins with a single polypeptide molecule anchored to a surface. As the protein degrades, its terminal amino acids are exposed. Specialized recognition molecules, including SH2 domain-containing proteins, bind to each amino acid. These interactions produce a unique series of signal pulses—each pattern corresponding to a specific amino acid.
This system can also detect important post-translational modifications, such as phosphorylation, which play a key role in diseases like cancer.
Why It Matters
Traditional protein analysis methods often require large sample sizes and deliver averaged results. In contrast, Quantum-Si’s approach offers precise, molecule-level data. The system identifies amino acids by analyzing the duration and timing of the signal pulses created during binding events.
This level of detail enables deeper insights into cellular processes and disease mechanisms, paving the way for advances in diagnostics, drug development, and personalized medicine.
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The method integrates hardware and software to rapidly interpret the signal patterns. This helps researchers efficiently map protein structures and variations with high accuracy.
With its single-molecule focus and real-time capabilities, Quantum-Si’s innovation represents a major leap in protein science.
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