New Hampshire Patent of the Month – March 2025
Adimab, LLC has secured U.S. Patent No. 12,258,679 for its innovative method titled “Polyclonal mixtures of antibodies, and methods of making and using them.” This advancement promises to enhance antibody therapies by broadening their target range and improving immune responses.
Expanding Antibody Diversity
Traditional monoclonal antibodies focus on a single epitope, which can limit their effectiveness against complex antigens. Adimab’s patented approach addresses this by generating polyclonal antibody mixtures through iterative selection processes. By exposing antigens to diverse antibody libraries and selecting for high-affinity binders, the method produces a comprehensive antibody repertoire.
This technique allows for the creation of antibody mixtures that can target multiple epitopes on an antigen, potentially leading to more robust therapeutic effects. Such diversity is particularly beneficial in treating diseases where pathogens or cancer cells exhibit high variability.
Implications for Therapeutic Development
The ability to produce tailored polyclonal antibodies opens new avenues in therapeutic development. These mixtures can offer enhanced efficacy and reduced resistance compared to monoclonal therapies. Adimab’s method could accelerate the development of treatments for complex diseases, including various cancers and infectious diseases.
By refining antibody diversity and selection, Adimab continues to lead in antibody engineering, providing tools that may significantly impact future therapeutic strategies.
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