Pennsylvania Patent of the Month – April 2025
Marinus Pharmaceuticals has secured a new U.S. patent for its epilepsy drug ganaxolone, advancing treatment options for patients with a rare genetic disorder. The patent could expand the drug’s use to a broader patient population with limited therapeutic alternatives.
The patent, U.S. Patent No. 12,268,696, is titled “Ganaxolone for use in treating tuberous sclerosis complex and seizure disorders.” It covers methods of treating tuberous sclerosis complex (TSC) and related seizure disorders using ganaxolone or its pharmaceutically acceptable salts.
A Targeted Dosing Strategy
The invention includes a detailed dosing regimen, starting at 150 milligrams per day and increasing weekly to a maintenance dose of up to 1800 milligrams per day. This structured approach is designed to balance safety and effectiveness, especially for patients sensitive to neurological side effects.
Real-World Need and Market Potential
Tuberous sclerosis complex affects multiple organ systems and often causes drug-resistant seizures. Existing treatments can be inconsistent or poorly tolerated. Marinus’s patented use of ganaxolone addresses these challenges with a new mechanism of action and a flexible dosing schedule.
Strategic Milestone for Marinus
This patent strengthens Marinus’s intellectual property position in the neurology space. It also supports continued research and development aimed at expanding therapeutic uses for ganaxolone.
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