Fairbanks, Alaska Patent of the Year – 2024/2025
University Of Alaska Fairbanks has been awarded the 2024/2025 Patent of the Year for their innovative approach to metabolic modulation. Their invention, detailed in U.S. Patent No. 11911408, titled ‘Synergistic formulations of adenosine receptor modulating agents and anticholinergics’, introduces a novel pharmaceutical composition designed to suppress metabolism without causing hypotension or bradycardia.
This formulation combines an A1 adenosine receptor (A1AR) agonist, such as 6-N-cyclohexyladenosine (CHA), with an A1AR antagonist like 8-(p-sulfophenyl)theophylline (8-SPT), and an anticholinergic agent, typically atropine. The unique combination allows for controlled metabolic suppression, which is particularly beneficial in clinical settings requiring induced hypothermia or metabolic depression without the adverse cardiovascular effects commonly associated with such treatments.
Preclinical studies have demonstrated that this synergistic approach effectively reduces metabolic rate and body temperature while maintaining stable blood pressure and heart rate. The composition’s ability to mitigate CHA-induced hypotension and bradycardia makes it a promising candidate for applications in trauma care, surgery, and other medical procedures where controlled metabolic suppression is necessary.
With this patent, the University of Alaska Fairbanks continues to contribute to advancements in medical science, offering a safer and more effective method for managing metabolic processes in critical care environments.
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