Pasadena, California Patent of the Year – 2024/2025
Lixte Biotechnology Inc. has been awarded the 2024/2025 Patent of the Year for its groundbreaking cancer-targeted prodrug innovation. Their invention, detailed in U.S. Patent No. 11866444, titled ‘Oxabicycloheptane prodrugs’, utilizes a novel oxabicycloheptane-based compound to deliver endothall directly to cancer cells.
This patented method enables precise in vivo delivery of endothall, a potent anti-cancer agent, to malignant cells while minimizing exposure to healthy tissue. The technology holds particular promise for treating aggressive brain cancers such as glioblastoma multiforme and medulloblastoma. By improving drug targeting, it aims to enhance treatment efficacy and reduce side effects.
The innovation builds upon Lixte’s lead compound, LB-100, a first-in-class PP2A inhibitor currently under clinical investigation. LB-100 is being tested in combination with immunotherapies at leading institutions, including MD Anderson Cancer Center and the Netherlands Cancer Institute. These trials explore its potential to boost immune response and improve outcomes in ovarian and colorectal cancers .
Lixte’s expanding patent portfolio underscores its commitment to advancing targeted cancer therapies. The company’s focus on precision delivery systems reflects a broader trend in oncology toward personalized, less toxic treatments. As clinical trials progress, this latest patent positions Lixte at the forefront of next-generation cancer drug development.