Biotechnology R&D Tax Credit Benefits for Businesses

Small businesses in the biotechnology industry can significantly benefit from the Research and Development tax credit by reducing their tax liability through qualified research expenses. For startups with little or no income tax liability, the Research and Development payroll tax offset offers a valuable alternative—allowing them to apply up to $500,000 of the credit annually against payroll taxes. This helps ease early-stage financial strain by directly offsetting a portion of payroll costs, freeing up cash to reinvest in research, development, and innovation. It’s a crucial incentive that supports biotech startups in scaling breakthroughs while managing tight budgets.

Are you eligible?

Why choose us?

Pass an Audit?

Swanson Reed is one of the only companies in the United States to exclusively focus on R&D tax credit preparation. Swanson Reed provides state and federal R&D tax credit preparation and audit services to all 50 states.

If you have any questions or need further assistance, please call or email our CEO, Damian Smyth on (800) 986-4725. Feel free to book a quick teleconference with one of our national R&D tax credit specialists at a time that is convenient for you.

Schedule a Teleconference

West Virginia Patent of the Month – May 2025

June 3, 2025 Biotechnology, West Virginia Patent of the Month

Modulation Therapeutics Inc. has unveiled a new class of cancer-fighting compounds in U.S. Patent Application No. 20250136642, titled ‘Cyclic peptide compounds and methods of use [...]

Biotechnology Case Study

Business Scenario

American Animal Nutrition Organization (AANO) is dedicated to providing natural, non-antibiotic solutions to varied animal health and nutrition issues.

In 2012, AANO decided to take part in an eight-year study to ensure that American beef was a high quality meat that was environmentally responsible, safe and nutritious. AANO created a hypothesis for this program of investigation which stated,

“With knowledge of the intrinsic factors regulating the metabolism of the gastrointestinal tract, we can identify mechanisms for improving feed intake, enhancing feed efficiency and reducing the reliance on antibiotic use.”

The first research phase of AANO’s R&D study involved identifying the intrinsic factors that regulated feed intake in the cow and developing a suitable, low temperature, high moisture pellet that facilitated the ingestion of the feed by cows.

To achieve its technical objectives and overcome the related technical risks, the AANO generated new knowledge at the conclusion of each experimental stage and built upon that knowledge at every stage of the remaining project.

After undergoing its first year of experimentation, AANO needed to determine the eligibility of its proposed R&D activities in order to know if they qualified as Research and Experimentation Tax Credit. To be eligible, AANO had to be certain that its “qualified research” met four main criteria, known and developed by Congress as the Four-Part Test. After self-assessing, AANO decided to register the following R&D expenditures with the IRS.

Never miss a deadline again

Stay up to date on IRS processes

Discover R&D in your industry

AANO’s Eligible R&D Activities

Design and development of a series of prototypes to achieve the technical objectives and prove the hypothesis (design and adaptation of the chemosensory testing model).

AANO’s main objective for this activity was to determine whether a model for identifying cow preferences based on the chemosensory properties of an ingredient could be designed and developed. This experimentation phase included:

Identification of substances known to have an impact on feed intake and efficiency.
Validation of a model for identifying cow preferences based on the chemosensory properties of an ingredient.
Determination of the statistical sensitivity of the model for identifying the preferences of different ingredients and purification of feed ingredients.
Determining of optimal feed processing conditions for retaining the intake improvement of an ingredient in a commercially relevant cow feed.

Trials and analysis of data to achieve results that can be reproduced to a satisfactory standard (development and testing of feed intake and efficiency enhancers).

The hypothesis for this AANO activity stated that with improved knowledge of the intrinsic factors regulating the metabolism of the gastrointestinal tract, it was possible to identify mechanisms for improving feed intake, enhancing feed efficiency and reducing the reliance on antibiotic use.

Details of this experiment included development of the enhancers based on information gained through the model and testing of the enhancers to ensure efficiency, accuracy and safety.

Background research to evaluate current knowledge gaps and determine feasibility (background research for feed intake and efficiency stimulants).

AANO’s background research included literature search and review, consultations with industry professionals and potential customers, and preliminary equipment and resources review.

The activities conducted during the background research were eligible because they assisted in identifying the key elements of the research project.

Ongoing analysis of customer or user feedback to improve the prototype design (feedback R&D of the feed intake and efficiency enhancers).

AANO’s eligible R&D activity for this phase of its project included:

Ongoing analysis and testing to improve the efficiency and safety of the project.
Ongoing development and modification to interpret the experimental results and draw conclusions that served as starting points for the development of new hypotheses.
Commercial analysis and functionality review.

These activities were necessary to evaluate the performance capabilities of the new design in the field and to improve any flaws in the design, therefore qualifying as R&D.

Live Webinar: The R&D Tax Credit in the Biotechnology Industry

Duration: 60 Minutes

Learning objectives include:

An overview of R&D Tax Credits
Identify Qualifying Research Activities
Define the 4-Part Test
How to substantiate activities through documentation
Identify Qualifying Research Expenses

Cost: FREE

CE/CPE credits: Worth one hour

Knowledge Level: Basic*

Field of Study: Taxation

R&D Tax Credit Training for the Biotechnology Industry

directive for LBI taxpayers

Upcoming Webinar

Qualified Research Defined

Qualified research consists of research for the intent of developing new or improved business components. A business component is defined as any product, process, technique, invention, formula, or computer software that the taxpayer intends to hold for sale, lease, license, or actual use in the taxpayer’s trade or business.

The Four-Part Test

Activities that are eligible for the R&D Credit are described in the “Four-Part Test” which must be met for the activity to qualify as R&D.

Permitted Purpose: The purpose of the activity or project must be to create new (or improve existing) functionality, performance, reliability, or quality of a business component.
Elimination of Uncertainty: The taxpayer must intend to discover information that would eliminate uncertainty concerning the development or improvement of the business component. Uncertainty exists if the information available to the taxpayer does not establish the capability of development or improvement, method of development or improvement, or the appropriateness of the business component’s design.
Process of Experimentation: The taxpayer must undergo a systematic process designed to evaluate one or more alternatives to achieve a result where the capability or the method of achieving that result, or the appropriate design of that result, is uncertain at the beginning of the taxpayer’s research activities.
Technological in Nature: The process of experimentation used to discover information must fundamentally rely on principles of hard science such as physical or biological sciences, chemistry, engineering or computer science.
What records and specific documentation did AANO keep?

Similar to any tax credit or deduction, AANO had to save business records that outlined what it did in its R&D activities, including experimental activities and documents to prove that the work took place in a systematic manner.

AANO saved the following documentation:

Background research
Project records and laboratory notebooks
Photographs / videos of extrusion process
Testing protocols
Results or analysis from testing / trial runs
Records of resource allocation / usage logs
Tax invoices

By having these records on file, AANO confirmed that it was “compliance ready” — meaning if it was audited by the IRS, it could present documentation to show the progression of its R&D work.

Click here for the PDF version of this case study.