California Patent of the Month – July 2025
A new patent from BioFluidica Inc. promises a significant leap forward in liquid biopsy technology. The invention, U.S. Patent No. 12350669, titled ‘Dual-depth thermoplastic microfluidic device and related systems and methods’, addresses challenges in isolating biomarkers from bodily fluids. This technology improves on existing methods for capturing rare biomarkers. It offers a more efficient and integrated platform for medical diagnostics.
A New Approach to Diagnostics
Liquid biopsies offer a non-invasive way to detect disease. They analyze biomarkers like circulating tumor cells and DNA. Current isolation methods can be difficult. They often require manual operation and specialized equipment. This new device integrates with automated lab systems. It uses a dual-depth design. This allows for better flow control and improved analyte recovery.
How It Works
The device is a thermoplastic substrate. It has microchannels and isolation beds with microposts. The microposts can be modified with capture elements. These elements selectively bind to biomarkers. The channels are designed with two different heights. This unique design helps control the fluid flow. It ensures the biomarkers are efficiently captured. The system can isolate nucleic acids and extracellular vesicles. It is effective even with very low concentrations of these markers. The invention is a step towards fully automated, high-throughput diagnostic systems.
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